{"id":888,"date":"2014-03-26T15:41:18","date_gmt":"2014-03-26T20:41:18","guid":{"rendered":"http:\/\/sciencemediacentre.ca\/site\/?p=888"},"modified":"2014-04-06T16:18:26","modified_gmt":"2014-04-06T21:18:26","slug":"how-drug-holidays-may-improve-cancer-treatment","status":"publish","type":"post","link":"http:\/\/sciencemediacentre.ca\/site\/how-drug-holidays-may-improve-cancer-treatment\/","title":{"rendered":"How \u2018drug holidays\u2019 may improve cancer treatment<img src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/01\/canada_flag_icon_small.gif\">"},"content":{"rendered":"<div id=\"attachment_889\" style=\"width: 455px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/04\/Melanoma-e1396818727714.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-889\" class=\"size-full wp-image-889\" alt=\"It is estimated that over 6000 Canadians were diagnosed with melanoma in 2013, and over an estimated 1000 Canadians passed away. (Credit: National Cancer Institute of the United States, Wikimedia Commons)\" src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/04\/Melanoma-e1396818727714.jpg\" width=\"445\" height=\"309\" \/><\/a><p id=\"caption-attachment-889\" class=\"wp-caption-text\">It is estimated that over 6000 Canadians were diagnosed with melanoma in 2013, and over an estimated 1000 Canadians passed away. (Credit: National Cancer Institute of the United States, <a href=\"http:\/\/commons.wikimedia.org\/wiki\/File:Melanoma.jpg\">Wikimedia Commons<\/a>)<\/p><\/div>\n<p>Studies on melanomas in mice have shown that tumors which developed resistance to the anti-cancer drug vemurafenib could regain sensitivity to the treatment after a \u2018drug holiday\u2019.<\/p>\n<p>A new study shows that melanoma human patients that have developed resistance can regain sensitivity to the drug after a drug holiday of seven days. This means that the patients could be re-treated with the same drug after a week-long hiatus.<\/p>\n<p><!--more--><\/p>\n<p><a href=\"http:\/\/www.nature.com\/nature\/journal\/v508\/n7494\/full\/nature13121.html\" target=\"_blank\"><span style=\"text-decoration: underline;\">Original research paper<\/span><\/a>\u00a0published in the\u00a0journal\u00a0<em>Nature <\/em>on\u00a0<strong>March 2<\/strong><strong>6, 2014<\/strong>.<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>Names and affiliations of selected<\/strong><strong>\u00a0authors<\/strong><\/span><\/p>\n<h4><a href=\"http:\/\/www.nki.nl\/divisions\/molecular-carcinogenesis\/bernards-r-group\/\" target=\"_blank\">Rene Bernards<\/a>, Netherlands Cancer Institute<\/h4>\n<h4><a href=\"https:\/\/www.mcgill.ca\/biochemistry\/about-us\/department\/faculty-members\/sidong-huang\" target=\"_blank\">Sidong Huang<\/a>, McGill University<\/h4>\n","protected":false},"excerpt":{"rendered":"<p>Studies on melanomas in mice have shown that tumors which developed resistance to the anti-cancer drug vemurafenib could regain sensitivity to the treatment after a \u2018drug holiday\u2019. A new study shows that melanoma human patients that have developed resistance can regain sensitivity to the drug after a drug holiday of seven days. This means that [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":889,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[25],"tags":[49,51,53],"class_list":["post-888","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-paper-of-interest","tag-cancer","tag-health","tag-medicine"],"jetpack_featured_media_url":"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/04\/Melanoma-e1396818727714.jpg","jetpack_shortlink":"https:\/\/wp.me\/p4DqbN-ek","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/comments?post=888"}],"version-history":[{"count":1,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/888\/revisions"}],"predecessor-version":[{"id":891,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/888\/revisions\/891"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media\/889"}],"wp:attachment":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media?parent=888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/categories?post=888"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/tags?post=888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}