{"id":6475,"date":"2018-12-06T11:00:34","date_gmt":"2018-12-06T16:00:34","guid":{"rendered":"http:\/\/sciencemediacentre.ca\/site\/?p=6475"},"modified":"2018-12-14T16:35:26","modified_gmt":"2018-12-14T21:35:26","slug":"mapping-inheritance-of-rare-genetic-disease-in-french-canadians","status":"publish","type":"post","link":"http:\/\/sciencemediacentre.ca\/site\/mapping-inheritance-of-rare-genetic-disease-in-french-canadians\/","title":{"rendered":"Mapping inheritance of rare genetic disease in French Canadians  <img src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/01\/canada_flag_icon_small.gif\">"},"content":{"rendered":"<p><a href=\"https:\/\/doi.org\/10.1016\/j.ajhg.2018.10.017.\" target=\"_blank\"><em>American Journal of Human Genetics<\/em><\/a><br \/>\n<strong>Published\u00a0December 6, 2018<\/strong><br \/>\nThis study presents an efficient method to infer transmission paths of rare genes through population-scale genealogies. Using a high-quality genealogical dataset of more than three million individuals related to the founding families of Quebec, researchers apply the method to reconstruct the transmission history of a rare recessive-gene disease. They identify the most likely early carriers of the mutation and geographically map the expected carrier rate in Quebec\u2019s French-Canadian population today.<\/p>\n<p><strong>Corresponding author: <\/strong>Simon Gravel, McGill University &#8211; <a href=\"mailto:simon.gravel@mcgill.ca\" target=\"_blank\">simon.gravel@mcgill.ca<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>American Journal of Human Genetics Published\u00a0December 6, 2018 This study presents an efficient method to infer transmission paths of rare genes through population-scale genealogies. Using a high-quality genealogical dataset of more than three million individuals related to the founding families of Quebec, researchers apply the method to reconstruct the transmission history of a rare recessive-gene [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1327,3259],"tags":[],"class_list":["post-6475","post","type-post","status-publish","format-standard","hentry","category-article-scientifique","category-heads-up"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4DqbN-1Gr","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/6475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/comments?post=6475"}],"version-history":[{"count":1,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/6475\/revisions"}],"predecessor-version":[{"id":6479,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/6475\/revisions\/6479"}],"wp:attachment":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media?parent=6475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/categories?post=6475"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/tags?post=6475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}