{"id":6266,"date":"2018-09-04T11:00:21","date_gmt":"2018-09-04T15:00:21","guid":{"rendered":"http:\/\/sciencemediacentre.ca\/site\/?p=6266"},"modified":"2018-09-10T21:47:26","modified_gmt":"2018-09-11T01:47:26","slug":"uncommon-mutations-affect-prognosis-in-estrogen-receptor-positive-breast-cancer","status":"publish","type":"post","link":"http:\/\/sciencemediacentre.ca\/site\/uncommon-mutations-affect-prognosis-in-estrogen-receptor-positive-breast-cancer\/","title":{"rendered":"Uncommon mutations affect prognosis in estrogen receptor\u2013positive breast cancer<img src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/01\/canada_flag_icon_small.gif\">"},"content":{"rendered":"<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-018-05914-x\" target=\"_blank\"><em>Nature Communications<\/em><\/a><br \/>\n<strong>Published\u00a0September 4, 2018<\/strong>\u00a0(<a href=\"https:\/\/press.nature.com\/?post_type=press_release&amp;p=123301\" target=\"_blank\">News release<\/a> at Nature Research Press)<br \/>\nUncommon mutations in three genes in estrogen receptor\u2013positive breast cancer negatively affect disease prognosis. Researchers studied archival breast cancer DNA from three cohorts of post-menopausal and pre-menopausal patients with hormone receptor\u2013positive breast cancer and found associations with poor clinical outcomes in estrogen receptor\u2013positive breast cancer for mutations in the genes\u00a0NF1,\u00a0PIK3R1, and\u00a0DDR1.<br \/>\n<strong>Canadian co-authors:<\/strong> Samuel Leung, University of British Columbia &#8211;\u00a0<a href=\"mailto:lsamuel@mail.ubc.ca\" target=\"_blank\">lsamuel@mail.ubc.ca<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature Communications Published\u00a0September 4, 2018\u00a0(News release at Nature Research Press) Uncommon mutations in three genes in estrogen receptor\u2013positive breast cancer negatively affect disease prognosis. Researchers studied archival breast cancer DNA from three cohorts of post-menopausal and pre-menopausal patients with hormone receptor\u2013positive breast cancer and found associations with poor clinical outcomes in estrogen receptor\u2013positive breast cancer [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1327,25],"tags":[],"class_list":["post-6266","post","type-post","status-publish","format-standard","hentry","category-article-scientifique","category-paper-of-interest"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4DqbN-1D4","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/6266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/comments?post=6266"}],"version-history":[{"count":1,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/6266\/revisions"}],"predecessor-version":[{"id":6267,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/6266\/revisions\/6267"}],"wp:attachment":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media?parent=6266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/categories?post=6266"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/tags?post=6266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}