{"id":4800,"date":"2016-05-16T23:48:59","date_gmt":"2016-05-17T03:48:59","guid":{"rendered":"http:\/\/sciencemediacentre.ca\/site\/?p=4800"},"modified":"2016-05-16T23:48:59","modified_gmt":"2016-05-17T03:48:59","slug":"warmer-labs-for-mice-make-for-more-accurate-cancer-research-results","status":"publish","type":"post","link":"http:\/\/sciencemediacentre.ca\/site\/warmer-labs-for-mice-make-for-more-accurate-cancer-research-results\/","title":{"rendered":"Warmer labs for mice make for more accurate cancer research results"},"content":{"rendered":"<div id=\"attachment_4801\" style=\"width: 650px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-4801\" class=\"size-full wp-image-4801\" src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2016\/05\/640px-Lab_mouse_mg_3213.jpg\" alt=\"Image via Wikimedia Commons under CC2.0\" width=\"640\" height=\"427\" srcset=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2016\/05\/640px-Lab_mouse_mg_3213.jpg 640w, http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2016\/05\/640px-Lab_mouse_mg_3213-300x200.jpg 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><p id=\"caption-attachment-4801\" class=\"wp-caption-text\"><em>Image via <a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Lab_mouse_mg_3213.jpg\">Wikimedia Commons under CC2.0<\/a><\/em><\/p><\/div>\n<p><strong><span style=\"font-weight: 400;\">New research shows that keeping laboratory mice warmer could mean more realistic results in cancer research studies. Lab temperatures are often 4-10 degrees colder that the toasty 30 degrees Celsius preferred by mice. Authors of a new study out of <\/span><span style=\"font-weight: 400;\">Roswell Park Cancer Institute in Buffalo, New York,<\/span><span style=\"font-weight: 400;\"> suggest the mice use more energy to keep warm in a cooler lab environment. This behavior could affect how the animals respond to cancer and treatments. Lead study author Elizabeth Repasky says the researchers are \u201cconcerned that too many publications in which results differ, either between labs in various countries or within the same lab, may be due to environmental conditions.\u201d Colder environments cause chronic metabolic stress in mice, which can promote\u00a0tumor growth and metastasis and slow down recovery.<\/span><\/strong><\/p>\n<p><strong>Authors:<\/strong><\/p>\n<p><strong><span style=\"font-weight: 400;\">Kathleen M. Kokolus, Maegan L. Capitanoa, Chen-Ting Lee, Jason W.-L. Eng, Jeremy D. Waight, Bonnie L. Hylander, Sandra Sexton, Chi-Chen Hong, Christopher J. Gordon, Scott I. Abrams &amp; Elizabeth A. Repasky.<\/span><\/strong><\/p>\n<p><strong>Corresponding author:<\/strong><\/p>\n<p><strong><span style=\"font-weight: 400;\">Elizabeth A. Repasky<\/span><\/strong><\/p>\n<p><a title=\"Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature\" href=\"http:\/\/www.pnas.org\/content\/110\/50\/20176\" target=\"_blank\">Original paper,<\/a> published on April 19, 2016 in the <em>Proceedings of the National Academy of Sciences in the United States of America<\/em>.<\/p>\n<p><a title=\"Chilly lab mice skew cancer studies\" href=\"http:\/\/www.nature.com\/news\/chilly-lab-mice-skew-cancer-studies-1.14190\" target=\"_blank\">Associated news story<\/a>, published in Nature.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New research shows that keeping laboratory mice warmer could mean more realistic results in cancer research studies. Lab temperatures are often 4-10 degrees colder that the toasty 30 degrees Celsius preferred by mice. Authors of a new study out of Roswell Park Cancer Institute in Buffalo, New York, suggest the mice use more energy to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4801,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[25],"tags":[49,2541,2434,2543],"class_list":["post-4800","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-paper-of-interest","tag-cancer","tag-laboratory-mice","tag-t-cells","tag-tumor-growth"],"jetpack_featured_media_url":"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2016\/05\/640px-Lab_mouse_mg_3213.jpg","jetpack_shortlink":"https:\/\/wp.me\/p4DqbN-1fq","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4800","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/comments?post=4800"}],"version-history":[{"count":3,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4800\/revisions"}],"predecessor-version":[{"id":4911,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4800\/revisions\/4911"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media\/4801"}],"wp:attachment":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media?parent=4800"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/categories?post=4800"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/tags?post=4800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}