{"id":4771,"date":"2016-04-12T23:31:02","date_gmt":"2016-04-13T03:31:02","guid":{"rendered":"http:\/\/sciencemediacentre.ca\/site\/?p=4771"},"modified":"2016-04-18T00:50:01","modified_gmt":"2016-04-18T04:50:01","slug":"people-with-disease-causing-mutations-who-remain-mysteriously-healthy","status":"publish","type":"post","link":"http:\/\/sciencemediacentre.ca\/site\/people-with-disease-causing-mutations-who-remain-mysteriously-healthy\/","title":{"rendered":"People with disease-causing mutations who remain mysteriously healthy<img src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/01\/canada_flag_icon_small.gif\">"},"content":{"rendered":"<p><a href=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-110\" src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english2.jpg\" alt=\"SMCC-english2\" width=\"255\" height=\"126\" \/><\/a><\/p>\n<p>Researchers have identified 13 people who appear to be healthy, despite carrying genetic mutations associated with severe childhood disease.\u00a0Researchers identified these individuals after performing genomic analysis on more than half a million people.<\/p>\n<p>The team believes their study provides a first step toward pinpointing genetic variants that may protect against childhood diseases currently thought to be caused by a single specific mutation. However further research will require identifying many more resilient individuals, a difficult task as these patients appear to be healthy in every way.<\/p>\n<p><a href=\"http:\/\/nature.com\/articles\/doi:10.1038\/nbt.3514\" target=\"_blank\"><span style=\"text-decoration: underline;\">Original research\u00a0paper<\/span><\/a>\u00a0published in\u00a0<em>Nature Biotechnology\u00a0<\/em>on <strong>April 11<\/strong><span class=\"aBn\" tabindex=\"0\" data-term=\"goog_453723367\"><span class=\"aQJ\"><strong>, 2015<\/strong>.<\/span><\/span><\/p>\n<p><span style=\"text-decoration: underline;\"><em><strong>Names and affiliations of selected\u00a0authors<\/strong><\/em><\/span><\/p>\n<h4><strong><span style=\"font-weight: 400;\">Eric Schadt, Icahn School of Medicine at Mount Sinai, New York, U.S.A.<\/span><\/strong><\/h4>\n<h4>Thomas J Hudson and Mathieu Lemire, Ontario Institute for Cancer Research, Toronto, Ontario<\/h4>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have identified 13 people who appear to be healthy, despite carrying genetic mutations associated with severe childhood disease.\u00a0Researchers identified these individuals after performing genomic analysis on more than half a million people. The team believes their study provides a first step toward pinpointing genetic variants that may protect against childhood diseases currently thought to [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[25],"tags":[1274,909,51,1813,50],"class_list":["post-4771","post","type-post","status-publish","format-standard","hentry","category-paper-of-interest","tag-dna","tag-genetics","tag-health","tag-mystery","tag-ontario"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4DqbN-1eX","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/comments?post=4771"}],"version-history":[{"count":1,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4771\/revisions"}],"predecessor-version":[{"id":4778,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4771\/revisions\/4778"}],"wp:attachment":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media?parent=4771"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/categories?post=4771"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/tags?post=4771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}