{"id":4530,"date":"2016-01-13T13:22:06","date_gmt":"2016-01-13T18:22:06","guid":{"rendered":"http:\/\/sciencemediacentre.ca\/site\/?p=4530"},"modified":"2016-01-18T01:06:55","modified_gmt":"2016-01-18T06:06:55","slug":"mammals-including-humans-shape-their-microbiome","status":"publish","type":"post","link":"http:\/\/sciencemediacentre.ca\/site\/mammals-including-humans-shape-their-microbiome\/","title":{"rendered":"Mammals, including humans, shape their microbiome"},"content":{"rendered":"<p><a href=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-110\" src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english2.jpg\" alt=\"SMCC-english2\" width=\"255\" height=\"126\" \/><\/a><\/p>\n<p>Humans create small molecules inside\u00a0the GI tract to help regulate the\u00a0composition of gut microbes and to\u00a0protect against intestinal diseases. The\u00a0researchers believe the findings of the\u00a0study reveal a host defense mechanism\u00a0and show that microRNAs can be used to\u00a0regulate the microbiome of individuals.<\/p>\n<p>The researchers found microRNAs\u00a0produced by intestinal cells in both mice\u00a0and humans regulate the activity of\u00a0bacterial genes. The team transplanted\u00a0microRNAs from healthy mice to\u00a0microRNA\u00ad deficient mice, and\u00a0successfully restored the normal\u00a0composition of gut microbes while also\u00a0protecting against colon damage.<\/p>\n<p>The\u00a0researchers hope to apply their findings to\u00a0human patients.<\/p>\n<p><a href=\"http:\/\/www.cell.com\/cell-host-microbe\/abstract\/S1931-3128(15)00497-7\" target=\"_blank\"><span style=\"text-decoration: underline;\">Original research paper<\/span><\/a>\u00a0published in <em>Cell Host &amp; Microbe\u00a0<\/em>on <strong>January 13<\/strong><span class=\"aBn\" tabindex=\"0\" data-term=\"goog_453723367\"><span class=\"aQJ\"><strong>, 2015<\/strong>.<\/span><\/span><\/p>\n<p><span style=\"text-decoration: underline;\"><em><strong>Names and affiliations of selected\u00a0author<\/strong><\/em><\/span><\/p>\n<h4>Howard L. Weiner,\u00a0Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.<\/h4>\n","protected":false},"excerpt":{"rendered":"<p>Humans create small molecules inside\u00a0the GI tract to help regulate the\u00a0composition of gut microbes and to\u00a0protect against intestinal diseases. The\u00a0researchers believe the findings of the\u00a0study reveal a host defense mechanism\u00a0and show that microRNAs can be used to\u00a0regulate the microbiome of individuals. The researchers found microRNAs\u00a0produced by intestinal cells in both mice\u00a0and humans regulate the activity [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[25],"tags":[113,917,51,53,1654],"class_list":["post-4530","post","type-post","status-publish","format-standard","hentry","category-paper-of-interest","tag-biology","tag-evolution","tag-health","tag-medicine","tag-microbiology"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4DqbN-1b4","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4530","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/comments?post=4530"}],"version-history":[{"count":1,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4530\/revisions"}],"predecessor-version":[{"id":4533,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4530\/revisions\/4533"}],"wp:attachment":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media?parent=4530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/categories?post=4530"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/tags?post=4530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}