{"id":4282,"date":"2015-08-18T20:05:05","date_gmt":"2015-08-19T00:05:05","guid":{"rendered":"http:\/\/sciencemediacentre.ca\/site\/?p=4282"},"modified":"2015-08-24T11:59:03","modified_gmt":"2015-08-24T15:59:03","slug":"discovering-how-a-new-class-of-drugs-works-against-super-viruses","status":"publish","type":"post","link":"http:\/\/sciencemediacentre.ca\/site\/discovering-how-a-new-class-of-drugs-works-against-super-viruses\/","title":{"rendered":"Discovering how a new class of drugs works against super viruses"},"content":{"rendered":"<p><a href=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-110\" src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english2.jpg\" alt=\"SMCC-english2\" width=\"255\" height=\"126\" \/><\/a><\/p>\n<p>An emerging class of drugs, AMLPs <em>(antimicrobial lipopeptides<\/em>), shows promise in the fight against superbugs, yet until now researchers have lacked a molecular-level understanding of how they act.<\/p>\n<p>According to a new study AMLPs clump together to form microscopic balls called micelles, which selectively kill stick to bacterial membranes &#8211; a complex structure that is slower to mutate and develop resistance. Using molecular-dynamics simulations and calculations the researchers found that AMLPs prefer to bind to bacterial membranes as they form micelles. However before they clump together, AMLPs are more likely to bind to whatever membrane they encounter first, whether it is bacterial or mammalian.<\/p>\n<p><a href=\"http:\/\/www.cell.com\/biophysj\/abstract\/S0006-3495(15)00717-1\" target=\"_blank\"><span style=\"text-decoration: underline;\">Original research paper<\/span><\/a>\u00a0published in\u00a0<em>Biophysical Journal\u00a0<\/em>on\u00a0<strong>August 18<\/strong><span class=\"aBn\" tabindex=\"0\" data-term=\"goog_453723367\"><span class=\"aQJ\"><strong>, 2015<\/strong>.<\/span><\/span><\/p>\n<p><span style=\"text-decoration: underline;\"><em><strong>Names and affiliations of selected\u00a0author<\/strong><\/em><\/span><\/p>\n<h4>Alan Grossfield, Department of Biochemistry and Biophysics, University of Rochester Medical Center, New York, U.S.A.<\/h4>\n","protected":false},"excerpt":{"rendered":"<p>An emerging class of drugs, AMLPs (antimicrobial lipopeptides), shows promise in the fight against superbugs, yet until now researchers have lacked a molecular-level understanding of how they act. According to a new study AMLPs clump together to form microscopic balls called micelles, which selectively kill stick to bacterial membranes &#8211; a complex structure that is [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[25],"tags":[53],"class_list":["post-4282","post","type-post","status-publish","format-standard","hentry","category-paper-of-interest","tag-medicine"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4DqbN-174","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/comments?post=4282"}],"version-history":[{"count":1,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4282\/revisions"}],"predecessor-version":[{"id":4283,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4282\/revisions\/4283"}],"wp:attachment":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media?parent=4282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/categories?post=4282"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/tags?post=4282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}