{"id":4159,"date":"2015-07-13T12:37:32","date_gmt":"2015-07-13T17:37:32","guid":{"rendered":"http:\/\/sciencemediacentre.ca\/site\/?p=4159"},"modified":"2015-07-27T17:52:46","modified_gmt":"2015-07-27T22:52:46","slug":"small-cell-lung-cancer-occurs-when-two-genes-are-switched-off","status":"publish","type":"post","link":"http:\/\/sciencemediacentre.ca\/site\/small-cell-lung-cancer-occurs-when-two-genes-are-switched-off\/","title":{"rendered":"Small cell lung cancer occurs when two genes are switched off<img src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/01\/canada_flag_icon_small.gif\">"},"content":{"rendered":"<p><a href=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-110\" src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english2.jpg\" alt=\"SMCC-english2\" width=\"255\" height=\"126\" \/><\/a>Using whole-genome sequencing researchers found that small cell lung cancer (SCLC) occurs when both copies of two separate genes responsible for tumor suppression are switched off.<\/p>\n<p>The research team hopes this discovery will help the development of new treatments for SCLC, which usually results in patient-death within months.<\/p>\n<p>Researchers sequenced the genome of 110 tumor specimens and found that in all but two cases both copies of the genes, one from each parent, TP53 and RB1 were inactive.<\/p>\n<p><a href=\"http:\/\/nature.com\/articles\/doi:10.1038\/nature14664\" target=\"_blank\"><span style=\"text-decoration: underline;\">Original research paper<\/span><\/a>\u00a0published in\u00a0<em>Nature <\/em>on\u00a0<strong>July 13<\/strong><span class=\"aBn\" tabindex=\"0\" data-term=\"goog_453723367\"><span class=\"aQJ\"><strong>, 2015<\/strong>.<\/span><\/span><\/p>\n<p><span style=\"text-decoration: underline;\"><em><strong>Names and affiliations of selected\u00a0authors<\/strong><\/em><\/span><\/p>\n<h4 dir=\"ltr\">Roman Thomas, University of Cologne, Germany<\/h4>\n<h4 dir=\"ltr\">Anthony N. Karnezis, Vancouver General Hospital, B.C.<\/h4>\n","protected":false},"excerpt":{"rendered":"<p>Using whole-genome sequencing researchers found that small cell lung cancer (SCLC) occurs when both copies of two separate genes responsible for tumor suppression are switched off. The research team hopes this discovery will help the development of new treatments for SCLC, which usually results in patient-death within months. Researchers sequenced the genome of 110 tumor [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[25],"tags":[125,49,1274,909,51,53],"class_list":["post-4159","post","type-post","status-publish","format-standard","hentry","category-paper-of-interest","tag-british-columbia","tag-cancer","tag-dna","tag-genetics","tag-health","tag-medicine"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4DqbN-155","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/comments?post=4159"}],"version-history":[{"count":3,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4159\/revisions"}],"predecessor-version":[{"id":4221,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/4159\/revisions\/4221"}],"wp:attachment":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media?parent=4159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/categories?post=4159"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/tags?post=4159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}