{"id":3500,"date":"2014-11-17T15:02:04","date_gmt":"2014-11-17T20:02:04","guid":{"rendered":"http:\/\/sciencemediacentre.ca\/site\/?p=3500"},"modified":"2014-11-17T13:18:37","modified_gmt":"2014-11-17T18:18:37","slug":"how-zmapp-fights-ebola","status":"publish","type":"post","link":"http:\/\/sciencemediacentre.ca\/site\/how-zmapp-fights-ebola\/","title":{"rendered":"How ZMapp fights Ebola<img src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/01\/canada_flag_icon_small.gif\">"},"content":{"rendered":"<p><a href=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-115\" src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english3.jpg\" alt=\"SMCC-english3\" width=\"300\" height=\"126\" \/><\/a><\/p>\n<p>A new study highlights the biochemical mechanisms behind ZMapp, a promising experimental treatment against Ebola virus infection developed with the involvement of the Public Health Agency of Canada.<\/p>\n<p>Using single-particle electron microscopy, researchers determined the structures of each monoclonal antibody in the Zmapp cocktail and how each one binds to vulnerable sites on the Ebola virus. Two antibodies disrupt the ability of the Ebola virus to enter human cells, while a third antibody flags the virus for destruction by the body\u2019s immune system.<\/p>\n<p>The study furthers our understanding of antibody cocktails against Ebola virus and will help in the design of future treatments.<\/p>\n<p><a href=\"http:\/\/www.pnas.org\/cgi\/doi\/10.1073\/pnas.1414164111\" target=\"_blank\"><span style=\"text-decoration: underline;\">Original research paper<\/span><\/a>\u00a0published in <em>PNAS\u00a0<\/em>on\u00a0<span class=\"aBn\" tabindex=\"0\" data-term=\"goog_453723367\"><span class=\"aQJ\"><strong>November 17, 2014<\/strong>.<\/span><\/span><\/p>\n<p><span style=\"text-decoration: underline;\"><em><strong>Names and affiliations of selected\u00a0authors<\/strong><\/em><\/span><\/p>\n<h4 dir=\"ltr\"><span style=\"text-decoration: underline;\"><a href=\"http:\/\/www.scripps.edu\/research\/faculty\/ward\" target=\"_blank\">Andrew B. Ward<\/a><\/span>, The Scripps Research Institute,\u00a0U.S.A.<\/h4>\n<h4 dir=\"ltr\"><span style=\"text-decoration: underline;\"><a href=\"http:\/\/www.scripps.edu\/research\/faculty\/saphire\" target=\"_blank\">Erica Ollmann Saphire<\/a><\/span>, The Scripps Research Institute,\u00a0U.S.A.<\/h4>\n<h4 dir=\"ltr\">Gary Kobinger, National Microbiology Laboratory, Public Health Agency of Canada (PHAC)<\/h4>\n","protected":false},"excerpt":{"rendered":"<p>A new study highlights the biochemical mechanisms behind ZMapp, a promising experimental treatment against Ebola virus infection developed with the involvement of the Public Health Agency of Canada. Using single-particle electron microscopy, researchers determined the structures of each monoclonal antibody in the Zmapp cocktail and how each one binds to vulnerable sites on the Ebola [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[25],"tags":[869,2233,51,53,476],"class_list":["post-3500","post","type-post","status-publish","format-standard","hentry","category-paper-of-interest","tag-canada-en","tag-ebola","tag-health","tag-medicine","tag-public-health"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4DqbN-Us","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/3500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/comments?post=3500"}],"version-history":[{"count":2,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/3500\/revisions"}],"predecessor-version":[{"id":3503,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/3500\/revisions\/3503"}],"wp:attachment":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media?parent=3500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/categories?post=3500"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/tags?post=3500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}