{"id":1727,"date":"2014-05-28T13:30:53","date_gmt":"2014-05-28T18:30:53","guid":{"rendered":"http:\/\/sciencemediacentre.ca\/site\/?p=1727"},"modified":"2014-05-28T20:26:20","modified_gmt":"2014-05-29T01:26:20","slug":"scientists-reveal-how-leukemias-resist-drugs","status":"publish","type":"post","link":"http:\/\/sciencemediacentre.ca\/site\/scientists-reveal-how-leukemias-resist-drugs\/","title":{"rendered":"Scientists reveal how leukemias resist drugs<img src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/01\/canada_flag_icon_small.gif\">"},"content":{"rendered":"<p><a href=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-110\" src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2013\/12\/SMCC-english2.jpg\" alt=\"SMCC-english2\" width=\"255\" height=\"126\" \/><\/a><\/p>\n<p><span style=\"color: #000000;\">Scientists have determined how some leukemia cells resist treatment by current cancer drugs, opening the door to new ways of treating such cancers. <\/span><\/p>\n<p><span style=\"color: #000000;\">The team examined drug-resistant cancer cells in the lab and found that they had higher levels of a family of enzymes called UGT1A as well as another enzyme called GLI1.<\/span>Together, these enzymes result in a molecule called glucuronic acid getting added onto cancer drugs, which alters the drug\u2019s ability to kill cancer cells.<\/p>\n<p>By inhibiting these enzymes, scientists could increase the effectiveness of established leukemia drugs like ribavirin and Ara-C.<\/p>\n<p><a href=\"http:\/\/www.nature.com\/nature\/journal\/vaop\/ncurrent\/full\/nature13283.html\" target=\"_blank\"><span style=\"text-decoration: underline;\">Original research paper<\/span><\/a>\u00a0published in the the journal\u00a0<em>Nature\u00a0<\/em>on\u00a0<strong>May 28, 2014<\/strong>.<\/p>\n<p><span style=\"text-decoration: underline;\"><strong>Names and affiliations of selected\u00a0authors<\/strong><\/span><\/p>\n<h4><a style=\"color: #1155cc;\" href=\"http:\/\/www.iric.ca\/en\/research\/principal-investigators\/katherine-borden\/\" target=\"_blank\">Katherine Borden<\/a><span style=\"color: #000000;\">, Universit\u00e9 de Montr\u00e9al, Quebec<\/span><\/h4>\n","protected":false},"excerpt":{"rendered":"<p>Scientists have determined how some leukemia cells resist treatment by current cancer drugs, opening the door to new ways of treating such cancers. The team examined drug-resistant cancer cells in the lab and found that they had higher levels of a family of enzymes called UGT1A as well as another enzyme called GLI1.Together, these enzymes [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[25],"tags":[49,51,1627,53,476,849],"class_list":["post-1727","post","type-post","status-publish","format-standard","hentry","category-paper-of-interest","tag-cancer","tag-health","tag-leukemia","tag-medicine","tag-public-health","tag-quebec-en"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p4DqbN-rR","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/1727","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/comments?post=1727"}],"version-history":[{"count":2,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/1727\/revisions"}],"predecessor-version":[{"id":1758,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/1727\/revisions\/1758"}],"wp:attachment":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media?parent=1727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/categories?post=1727"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/tags?post=1727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}