{"id":1437,"date":"2014-05-10T13:09:15","date_gmt":"2014-05-10T18:09:15","guid":{"rendered":"http:\/\/sciencemediacentre.ca\/site\/?p=1437"},"modified":"2014-05-10T13:09:15","modified_gmt":"2014-05-10T18:09:15","slug":"dna-sensor-shines-light-on-cancer","status":"publish","type":"post","link":"http:\/\/sciencemediacentre.ca\/site\/dna-sensor-shines-light-on-cancer\/","title":{"rendered":"DNA sensor shines light on cancer<img src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/01\/canada_flag_icon_small.gif\">"},"content":{"rendered":"<div id=\"attachment_1425\" style=\"width: 410px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/05\/DNA-construct.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1425\" class=\"size-full wp-image-1425\" src=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/05\/DNA-construct.jpg\" alt=\"Researchers have created a DNA construct that contorts in response to tiny changes in pH, bringing together molecules that give off a light signal. The technology could be used to detect cancer and perhaps one day, to treat it. (Credit: Marco Tripodi)\" width=\"400\" height=\"477\" srcset=\"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/05\/DNA-construct.jpg 400w, http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/05\/DNA-construct-251x300.jpg 251w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/a><p id=\"caption-attachment-1425\" class=\"wp-caption-text\">Researchers have created a DNA construct that contorts in response to tiny changes in pH, bringing together molecules that give off a light signal. The technology could be used to detect cancer and perhaps one day, to treat it. (Credit: <a href=\"http:\/\/www.eurekalert.org\/multimedia\/pub\/72883.php?from=267053\">Marco Tripodi<\/a>)<\/p><\/div>\n<p><span style=\"color: #222222;\">Researchers have created a DNA-based sensor capable of lighting up when it gets near cancer cells. <\/span><\/p>\n<p><span style=\"color: #222222;\">The nano-sized construct alters its shape in response to tiny changes in pH; these contortions bring together two molecules which react to give off a light signal. <\/span><\/p>\n<p><span style=\"color: #222222;\">Because cancer cells are often at a slightly different pH than non-cancerous ones, these tunable constructs could be used to detect tumours. The same principle could also be used to construct other complexes that release drugs only when near cancer cells.<\/span><\/p>\n<p><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja500619w\" target=\"_blank\">Original research paper<\/a><a href=\"http:\/\/www.sciencemag.org\/content\/344\/6183\/495.abstract\" target=\"_blank\">\u00a0<\/a>published in the\u00a0<em>Journal of the American Chemical Society<\/em><i>\u00a0<\/i>on <strong>April 9<\/strong><strong>, 2014<\/strong>.<\/p>\n<p><span style=\"text-decoration: underline;\"><span><strong>Names and affiliations of selected\u00a0authors<\/strong><\/span><\/span><\/p>\n<h4><a style=\"color: #1155cc;\" href=\"http:\/\/www.chimie.umontreal.ca\/en\/people\/professors\/ValleeBelisle_Alexis\/\" target=\"_blank\">Alexis Val\u00e9e-Belisle<\/a><span style=\"color: #222222;\">, Universit\u00e9 de Montr\u00e9al, Quebec<\/span><\/h4>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have created a DNA-based sensor capable of lighting up when it gets near cancer cells. The nano-sized construct alters its shape in response to tiny changes in pH; these contortions bring together two molecules which react to give off a light signal. Because cancer cells are often at a slightly different pH than non-cancerous [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":1425,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[25],"tags":[49,1274,51,53,849],"class_list":["post-1437","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-paper-of-interest","tag-cancer","tag-dna","tag-health","tag-medicine","tag-quebec-en"],"jetpack_featured_media_url":"http:\/\/sciencemediacentre.ca\/site\/wp-content\/uploads\/2014\/05\/DNA-construct.jpg","jetpack_shortlink":"https:\/\/wp.me\/p4DqbN-nb","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/1437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/comments?post=1437"}],"version-history":[{"count":1,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/1437\/revisions"}],"predecessor-version":[{"id":1438,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/posts\/1437\/revisions\/1438"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media\/1425"}],"wp:attachment":[{"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/media?parent=1437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/categories?post=1437"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/sciencemediacentre.ca\/site\/wp-json\/wp\/v2\/tags?post=1437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}